Jornal Do Brasilia - At least one arrested over actor Matthew Perry's death: US media

NBC, citing law enforcement officials, said one arrest had been made, while TMZ said there had been "multiple" arrests including one doctor, as investigators probed how Perry obtained the drug.

Perry, who played Chandler Bing on the hit TV sitcom from 1994-2004, was found unresponsive in his pool in October last year at the age of 54, sparking a global outpouring of grief from fans and colleagues.

An autopsy found the cause of his death was "the acute effects of ketamine," a controlled drug which the recovering addict was understood to be taking as part of supervised therapy.

While only small amounts were found in his stomach, a high level was detected in his bloodstream.

Just how the actor -- who had reportedly not had a supervised infusion session for several days -- obtained the drug became the subject of a legal investigation, with Los Angeles police confirming in May that they were probing the death.

Celebrity news site TMZ, citing law enforcement sources, reported that "at least one doctor has been arrested, along with several dealers who helped arrange and deliver ketamine to Perry."

Doctors and veterinarians often employ ketamine as an anesthetic, and researchers have explored its use as a treatment for depression. Underground users take it illicitly for its hallucinogenic effects.

"Friends," which followed the lives of six New Yorkers navigating adulthood, dating and careers, drew a massive global following and made megastars of previously unknown actors who became a fixture in the lives of millions of viewers.

But Perry's comic talent, which brought him fabulous wealth, hid a darkness that left him struggling with addictions to painkillers and alcohol.

His sudden death last year drew shocked reactions from Hollywood A-listers, his costars, and "Friends" fans worldwide.

E. da Cruz--JDB